Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. WHO classification of soft tissue and bone, fourth edition: summary and commentary. Our findings may provide a promising strategy for a subset of osteosarcoma patients with lung metastases. Disrupting the interaction between Rab22a-NeoF1 and SmgGDS-607 with a synthetic peptide prevents lung metastasis in an orthotopic model of osteosarcoma. This association facilitates the release of GTP-bound RhoA from SmgGDS-607, which induces increased activity of RhoA and promotes metastasis. The Rab22a 1–38 moiety governs the function of Rab22a-NeoFs by binding to SmgGDS-607, a GTP–GDP exchange factor of RhoA. The resulting translation products, designated Rab22a-NeoFs, acquire the ability to drive lung metastasis of osteosarcoma. These fusion genes are derived from chromosomal translocations that juxtapose the coding region for amino acids 1–38 of Rab22a (Rab22a 1–38) with multiple inverted introns and untranslated regions of chromosome 20. Here we identify exon–intron fusion genes in osteosarcoma cell lines and tissues. However, the molecular mechanisms of lung metastasis of osteosarcoma remain poorly understood. Osteosarcoma is a type of aggressive malignant bone tumour that frequently metastasizes to lungs, resulting in poor prognosis. Nature Cell Biology volume 22, pages 868–881 ( 2020) Cite this article Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |